Signs and wonders have specific purposes. God uses them to identify His message and help those who earnestly seek Him. He does not use them according to our agenda, but His. He will not continue to use signs and wonders in a person's life if they continue to ignore the more subtle ways He works and provides as well as the more obvious ways like His Word. Signs and wonders are tools to guide us into spiritual maturity. The trusting Christ-follower will understand that God works most often in ways we will never see (John 20:29).
We do not need signs and wonders to validate God’s messenger or message today. With the completion of God's Word and Jesus coming to earth, prophets are not the primary method by which we learn God's will and character. Instead, we are to trust in God individually and let Scripture guide our hearts. But, like the miracles God used to introduce Himself to His early followers, He still sometimes validates His message by showing seekers and new believers His power in miraculous ways. When someone first comes to Christ, they are often miraculously healed from a particular sin, they may see their prayers answered in powerful ways, and they may be suddenly aware of God's work directly in their lives.
The mistake is in assuming God will always interact with us in this way. Christians are to mature spiritually, relying on the Bible, leading from the Holy Spirit, and a strong faith in God's goodness and power rather than through signs and wonders. Signs and wonders are powerful, but they do not last. Often, we forget what was done. God does work through signs and wonders, so we can hope and pray for a miraculous deliverance; however, we also need spiritual maturity to accept that God acts according to His plan and our best. An unanswered prayer is not a sign that God deserted us, but that He has something planned we can't yet see. Our faith is based on something more solid than signs and wonders. Spiritual maturity and grounding in God’s Word allows us to take these signs and wonders and build on the faith God is already working in and through us.
For those who have rejected God and only ask for His help with bitterness and selfishness should not expect God to come to give them the miracle they want. Today we see this with people who demand, "God, I'll believe in You if You give me money" or, “God, I’ll believe in You if You heal my friend.” There are many who walk away from God because a loved one has died, with bitterness and anger toward God coming in because He did not act how they wanted Him to act. If we don't have faith to trust God with our lives and we don’t trust Him with what He has already shown us, it's entirely reasonable that miracles, signs, or wonders won’t satisfy our bitter demands either.