Worship and prayer are reserved for God alone, so worshiping idols or any created being is unbiblical (Exodus 20:3–5; Deuteronomy 5:7–9; Leviticus 19:4; Psalm 115:4–8). While Mary and the saints are honored as faithful servants of God, they are not sinless and cannot mediate salvation (Luke 1:28, 47; 1 Timothy 2:5). Besides showing that human beings direct worship to God alone (Acts 10:25–26), Scripture shows that angels do not accept worship and direct all glory to God (Revelation 19:10, 22:8–9). Prayer is an act of worship, and Scripture clearly instructs that believers approach God directly through Jesus, the one mediator (Hebrews 4:14-16; John 14:13–14). The Roman Catholic practice of praying to Mary or the saints blurs this distinction, addressing worship to created beings rather than God. True biblical prayer always acknowledges God as the ultimate source of grace, power, and salvation. Believers are, therefore, called to offer all prayer and worship to God alone, through Jesus Christ, empowered by the Holy Spirit.
Many a love song speaks of worshiping the beloved. Metaphors aside, only God is worthy of worship, and it's a serious antibiblical practice to worship anyone or anything besides Him. Roman Catholics, however, direct prayers to Mary and the saints, even though they claim that they are merely asking these figures to pray with them. Despite that claim, the Catechism of the Catholic Church plainly teaches, “We can pray with and to her” (part 4, section 1, chapter 2, article 2, paragraph 2679). This indicates that prayers are, in fact, addressed to Mary and other saints.
Many everyday Catholics pray to Mary or the saints without realizing that their actions are offensive to God. Believers should look for opportunities to speak with our Catholic friends and acquaintances about this. Questions can be a good way to broach the subject—e.g., asking about their practice to find out more and then asking, "Would you mind if I shared a few passages in the Bible that address how and whom to pray to?" You can show them that every instance of prayer, whether in the Psalms, the Gospels, or the Epistles, is always directed to God. Suppose they don't accept it? So be it. Our role as believers is to share the truth; God alone changes hearts.